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Ulinastatin is a serine protease inhibitor, which reduces the inflammatory response caused by proinflamatory cytokines. Ulinastatin downregualtes pro-inflammatory markers like TNF-alpha, IL-6 and reduces progression to MODS in Severe sepsis, Severe Acute Pancreatitis and similar conditions where cytokine storm prevails. Ulinastatin has shown established safety and proven efficacious in patients with sepsis and acute pancreatitis.To know more about use of U-Tryp in the management of Severe Sepsis and Acute Pancreatitis Click Here

U-Tryp mode of Action: Acute Pancreatitis

Acute pancreatitis ranges from a mild, self-limiting disease to a life-threatening condition with multiple organ failure with mortality as high as 30%. Such high mortality in severe acute pancreatitis is attributed to the massive inflammatory response which results in multiple organ failure. Trypsin secreted by the pancreatic acinar cells activates protease-activated receptor-2 which can result in the production of cytokines. Ulinastatin, which is a protease inhibitor, prevents trypsinogen to trypsin conversion and further activation of various enzymes and inflammatory response acute pancreatitis. In addition Ulinastatin inhibits the secretion of pro-inflammatory cytokines thus preventing further progression MODS in severe acute pancreatitis

U-Tryp Dosage

2,00,000 I.U. twice a day for 5 days diluted with 100ml 0.9% Normal Saline or 5% Dextrose

U-Tryp Patient Support Program

Bharat Serums and Vaccines nurtures bringing life to life as its vision, and we make this possible by bringing innovative life saving medications. But our responsibility does not end here, to ensure that these medicines are accessible to all patients alike, we have initiated two patient support programs. 1. Stamp out Sepsis 2. Freedom from Acute Pancreatitis Under both these program, we offer sample starter packs to patients who can not afford the entire therapy with U-Tryp. We execute these campaign by partnering with clinicians who help us identify these needy patients. To know more about the program or to request for samples, Submit the details as below

Scientific Support: Indian Trials

Will send you the artwork for the these, need to take from anthology of clinical evidence


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